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OncoAim®Tumor Multi-gene Mutation and Drug Metabolism Assay

Detection method

The next-generation sequencing (NGS) used in this assay, compared to PCR and Sanger sequencing methods, is able to simultaneously detect mutations in multiple genes or regions. A single test can provide more information on clinical diagnosis and treatment.

Test significance

The results of this array guide the clinical treatment of targeted drugs and chemotherapy drugs for common tumors.

Product advantage

- Sensitive: DNA samples as low as 2 ng may be used, which is applicable to fine needle biopsies of limited cell numbers.

- Precise: Automatic bioinformatics analysis to reduce human error. 

- Actionable:Detection of clinically meaningful targets to provide guidance for diagnosis and treatment. 

- Comprehensive:Simultaneous detection of somatic mutations and genotyping SNPs related to drug metabolism. Up to 6,000 hot spot mutations and over 40 SNP sites can be detected on one sample, covering common targeted drugs for cancer as well as chemotherapy drugs.

Detection of genes

Tumor genes(59)

  • ABL1
  • CDKN2A
  • EZH2
  • IDH2
  • MPL
  • PTCH1
  • STAT3
  • AKT1
  • CHEK2
  • FBXW7
  • JAK1
  • NFE2L2
  • PTEN
  • STK11
  • ALK
  • CSF1R
  • FGFR1
  • JAK2
  • NOTCH1
  • RAF1
  • TP53
  • APC
  • CTNNB1
  • FGFR2
  • JAK3
  • NPM1
  • RB1
  • U2AF1
  • ATM
  • DNMT3A

Drug metabolism genes(14)

    • ABCB1
    • CYP2C8
    • CYP3A4
    • DPYD
    • MYTHFR
    • SLC19A1
    • TPMT
    • CYP2C19
    • CYP2D6
    • CYP3A5
    • GSTP1
    • NQO1
    • SULT1A1
    • UGT1A1

Applicable to cancer patients

- Cancer patients receiving targeted therapy to identify patients who will benefit most from a specific targeted drug. 

- Cancer patients receiving multiple treatments to determine optimal treatment options and avoid toxic side effects of drugs, especially chemotherapy drugs. 

- Cancer patients who failed routine medical treatment to find the cause of drug resistance and potential target site.

Test procedure

*Product is for research use only.